TH influence cardiac function with different mechanisms: inotropic and chronotropic positive effect via nuclear and non-nuclear pathways in cardiomyocytes, increase in cardiac contractility through augmented tissue oxygen delivery and consumption decrease in systemic vascular resistance, through direct TH action on vascular smooth muscle cells other endocrine effects are exerted on renin-angiotensin-aldosterone axis and on erythropoietin secretion. ĭue to the importance of TH in cardiac function, it is not surprising that cardiac patients have been extensively studied under this profile. A retrospective study in a large group of patients treated with mechanical ventilation (MV) confirmed that NTIS represents a risk factor for prolonged MV. In a very recent paper in unselected ICU patients, free T 3 (fT 3) was the most powerful and the only independent predictor of ICU mortality, with a prognostic improving value when added to APACHE II score. Therefore we present a review of these recent results and some personal data in patients affected by chronic obstructive pulmonary disease and patients studied after major cardiovascular surgery.Ī low T 3 state has been described in a variety of clinical situations, such as starvation, sepsis, surgery, trauma, myocardial infarction and heart failure, cardiopulmonary bypass, respiratory failure, bone marrow transplantation, other severe illness. The role of intracellular oxidative stress (OS) has been underlined. The question is open and different reviews have been published on this topic but, very recently different molecular mechanisms have been shown to gain insight the complex situation of NTIS. Since there is no clear evidence of tissue hypothyroidism, such a condition seems to be an adaptative response, and thyroid replacement therapy is not usually required, but this topic is still debated, since indirect signs of true hypothyroidism at tissue levels have been showed. The hormonal response exhibits different pattern in acute and chronic phase, since in the first phase the alteration predominate in peripheral metabolism of TH, while in the latter central mechanisms controlling thyroid secretion progressively arise. Moreover, the severity of morbidity and outcome in patients studied in intensive care unit (ICU) has been correlated with the alteration in thyroid function. NTIS has been depicted in about 70% of hospitalized patients for different diseases. However, T 3 lowering is only one of the endocrine picture described is such a situation therefore the term NTIS seems to be more appropriate, also strengthening its extrathyroidal source. In critical illness, several abnormalities in thyroid hormone (TH) secretion, metabolism and action have been described in patients without previous diagnosis of intrinsic thyroid disease and are collectively called “Non thyroidal syndrome” (NTIS) this term is now largely employed, in the place of “euthyroid sick syndrome” or “low-T 3 syndrome”, due to the most common abnormality, a decreased level of serum total triiodothyronine (T 3), which can be detected very early, within 2 hours after the onset of severe physical stress.
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Thus, potential hearing loss present at the ages studied in C57BL/6 mice could have contributed to the observation of local frequency preference heterogeneity. In contrast, mice of the CBA strain or F1 offspring of C57BL/6 mice and CBA mice retain normal hearing into adulthood 31, 32, 33, 34, 35, 36. However, the C57BL/6 strain carries a mutant cdh23 allele 23, 24, 25, 26, 27, 28, 29 which leads to a progressive loss of hair cells from the basal turn of the cochlea 30, making these mice an ideal model of presbycusis 31, 32, 33, 34, 35. Many functional studies in mouse have been performed on mice on the C57BL/6 background. The precise degree of heterogeneity varies slightly between these studies, and this difference might be due to differences in anesthetic condition, cell inclusion criteria, tonal stimuli used, and/or species. However, the application of large-scale high-resolution optical techniques in mice or rats using synthetic dyes (OGB1, Fluo4, or Cal-520) or sensitive genetically encoded Ca 2+ indicators (GCaMP6) has shown that on the cellular level the organization of tuning in A1 is more heterogeneous than previously appreciated 1, 2, 3, 4, 5, 6, 19, 20, 21, 22 suggesting that at least in rodent layer 2/3 (L2/3) functional tonotopic maps might be fractured. A classic hallmark of A1 organization in all species has been the discovery of tonotopic maps which describe a smooth distribution of tone preference across the surface of the primary and secondary auditory fields when probed with low spatial resolution techniques 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18. Recent studies have investigated the functional organization and circuitry of mouse auditory cortex 1, 2, 3, 4, 5, 6. The primary auditory cortex (A1) plays a key role for sound perception since it represents one of the first cortical processing stations for sounds. The cerebral cortex is uniquely adapted to encode behaviorally relevant stimuli and generate appropriate behavioral actions. Our results demonstrate that the tone evoked responses and frequency representation in A1 of adult C57BL/6 and F1 (CBAxC57) mice are largely similar. The spatial heterogeneity of frequency preference was present in both strains with F1 (CBAxC57) mice exhibiting higher tuning diversity across all measured length scales. Frequency selectivity was slightly higher in C57BL/6 mice while neurons in F1 (CBAxC57) mice showed a greater sound-level sensitivity. Pure tones recruited neurons of widely ranging frequency preference in both layers and strains with neurons in F1 (CBAxC57) mice exhibiting a wider range of frequency preference particularly to higher frequencies. We used in vivo 2-photon imaging of pyramidal neurons in cortical layers L4 and L2/3 of awake mouse primary auditory cortex (A1) to characterize the populations of neurons that were active to tonal stimuli. Since potential strain differences could exist in A1 organization between strains, we performed comparative analysis of neuronal populations in A1 of adult (~ 10 weeks) C57BL/6 mice and F1 (CBAxC57) mice. In contrast, mice on the CBA background retain better hearing sensitivity in old age. However, many of these studies were performed in mice on the C57BL/6 background which develop high frequency hearing loss with age making them a less optimal choice for auditory research. Recent studies have shown that on the cellular level the frequency organization of A1 is more heterogeneous than previously appreciated. Meg would not hear of it and she shared her bubble and squeak with Crom and Og. Crom wanted to eat and suggested that Og might make a nice meal. There they met Crom, a caveman, and Og his trusty woolly mammoth. A bat fell into the caldron and it made Meg realise that she needed some more room so she cast a spell to that effect.īut the unexpected happened, the three of them, complete with caldron and broomstick, fell into a cold, damp cave. Meg the witch, was making bubble and squeak in her caldron while Mog the cat and Owl were having a bat hunt. Humorous and entertaining, this book will keep young readers involved through both story and art, and is recommended to younger children who enjoy witchy fare, or who are fans of these characters. My favorite touch, though, would undoubtedly be the next-to-last page, which shows a hungry Og's red trunk reaching through the window, seemingly in search of some bubble and squeak, as Meg and Mog snore away, and Owl suspiciously keeps one eye open. There is also beauty, as in the scene in which the characters are all depicted in silhouette - one of Pieńkowski's trademark styles - against receding circles of black, purple, blue and snowy-gray, together meant to represent the cave in which they are living. There's plenty of visual fun in Meg, Mog and Og, as the trio take cover from bats in the opening scene, or Meg turns a bright red, and tears out her hair in frustration, when their living quarters get a little small - an image that the reader is shown from above. Or so it seems.Īs with previous entries in this series, there is a great synergy here between Helen Nicoll's text, split between the straightforward narrative, and the exclamations and sound words contained in the speech bubbles, and Jan Pieńkowski's brightly-coloured artwork, which invariably accentuates the humour in each scene, and often adds a new dimension to the story itself. But life in a cave is cold (not to mention messy), so the witchy/feline/strigine trio soon return to the present, leaving Crom and Og behind. Fortunately, Meg has plenty of bubble and squeak on hand, and their new stone-age friends are convinced to try it, rather than each other. Here they meet a caveman named Crom, as well as Og, the wooly mammoth he has captured, and intends to eat. Meg, Mog and Owl find themselves tumbling through time in this sixteenth entry in the Meg and Mog picture-book series, winding up in a prehistoric cave when one of Meg's spells, intended to create more room - "Cabbage & onion / Cavern & canyon / Bucket & broom / A big new room" - goes horribly (and predictably) wrong. In addition to the MEG AND MOG series, Helen has a long and varied association with Puffin - as editor of the Junior Puffin magazine THE EGG from 1977 - 1979, as compiler of the popular children's poetry anthology POEMS FOR SEVEN YEAR OLDS AND UNDER, illustrated by Michael Foreman, and through her partnership with Puffin, the enormously popular series of Puffin Cover to Cover story tapes of which Helen is the Producer. The result is the immensely popular MEG AND MOG series. After working together for four years, they decided it was time to preserve their creativity in book form for future generations of children to enjoy. It was here, as Producer of the children's educational series WATCH, that she first met Jan Pienkowski. Helen Nicoll was a television producer with the BBC for many years. Helen Nicoll married Robert Kime in 1970 and they have one daughter and one son. She was educated at schools in Bristol Dartington Hall, Devon and Froebel Education Institute, London. Helen Nicoll was born in Natland, Westmorland, in 1937. While my goal had been to conquer Top Thrill Dragster and Millenium Force, another ride immediately caught my eye. I’d had a few opportunities to visit, but something had always come up. Joker - The least memorable of the ones I've ridden.still the best ride in the park.A couple of years ago, after more than 30 years of anticipation, I finally made my way to Cedar Point. I do like that you basically get 2 rides in a row though. Twisted Colossus - This was my first RMC and I love it but it doesn't have what it takes to compete with the 3 above. It's still a fantastic coaster and rounds out my top 3 coasters. The drop is straight instead of twisted and overall I didn't like it as well as the 2 above it. Steel Vengeance - Obviously this is the tallest fastest longest but in a lot of ways I found it the most vanilla. The dive off of the quarry wall is one of my favorite coaster elements anywhere. The way it twists next to the quarry wall is fantastic. Iron Rattler - This one has by far the best drop of the bunch. The quad down is amazing and I love the way it flies through the hills. Lightning Rod - Just a wild ride from start to finish. I've ridden 5 and I rank them a bit differently than everyone else. News Plus Notes - News and Articles Gaming Links Filter Subreddit PostsĬlick to filter posts by only THAT type of post.Īnnouncements and Official Discussion MegaThreads Do not post incorrect names, pictures, or stats from Google Maps, Wikipedia, news articles, park merchandise, movies, tv shows, or commercials. No Clickbait, Obvious Errors, or Unreliable Sources - Do not link to clickbait-style articles. The only exception to this rule is a Planet Coaster or No Limits POV from a coaster that's under construction but hasn't been announced yet (therefore there is no official POV yet). Those should go in their designated subs. No RCT, Planet Coaster, No Limits, Roblox, Minecraft, or Parkitect creations. No Advertising or Social Media Links - You may include a link at the end of a written trip report or in the weekly “General Discussion Thursday” thread. No Unofficial POVs - The majority of parks do not allow cameras on any ride non-transportation rides so this a zero-tolerance policy on the subreddit to make moderation easier. Everyone has a camera on their phone, but that doesn’t mean every single photo or video you take is worth posting. Don’t post photos of the same ride or park over and over.Include the name of the coaster or park! Not everyone has all coasters memorized.We don’t need your daily updates of ride construction. We want to keep the sub-reddit fresh and interesting, instead of repeating topics that have already been covered.ĭon't Post Too Frequently - Limit yourself to one post about a particular ride or park per week. Keep It Interesting (No Reposts) - Make sure your post is high quality and worth posting. See something that doesn’t align with the rules? Please use the report button and a mod will address it as soon as possible. Avoid posting low quality comments like “this coaster sucks” with no other opinions or context. If you wouldn't say it to their face, don’t say it online. r/RideForces - G-Force graphs of rides! Rules of this subredditīe Nice to Others - Follow Reddiquette, remember that we strive to be a close and friendly community. r/ThemeParkMaps - View and submit park maps! r/OnRidePhotos - Share your On Ride Photos! r/GuessTheCoaster - Play "Guess the Coaster" r/RollercoasterJerk - DAE MILLENNIUM FORCE? Visit Coast2Coaster for a worldwide map to see what coasters are near you or to help with planning a trip! Also try the new Coaster Calendar to see what parks are open what days!īe sure to check out our WEEKLY ADVICE THREAD stickied at the top of the page for any park-specific questions! Friends Visit Coaster-Count to start your own track record and see how many different coasters you've been on! Visit the Roller Coaster Database or RCDB for information and pictures on any roller coaster on the planet, past, present and future! New to the subreddit or the world of coasters?Ĭheck out this link for a list of commonly used acronyms or frequently asked questions! The NUMBER ONE* place on the internet for roller coaster and amusement park discussion, news and updates! Export reports into text files to review at a later time. It is easy to use and runs as a portable edition. Advanced IP Scanner is a free network scanner that can locate and analyze all computers available on your wireless or wired. Download Advanced IP Scanner for Windows now from Softonic: 100 safe and virus free. In simple terms, an IP scanner works either by conducting ICMP ping sweeps to find a range of IP addresses or by using SNMP scans to map network topology. In a matter of seconds, Advanced IP Scanner can locate all the computers on your wired or wireless local network and conduct a scan of their ports. We do not encourage or condone the use of this program if it is in violation of these laws. Advanced IP Scanner is a free, fast and powerful network scanner with a user-friendly interface. Laws concerning the use of this software vary from country to country. The program shows all network devices, gives you access to shared folders, provides remote control of computers (via RDP and Radmin), and can even remotely switch computers off. A full-fledged network simulation software from Cisco. From the program, you can remotely take over a PC, shut down the PC, or remove them from the network. Reliable and free network scanner to analyze LAN. Advanced IP Scanner is compatible with Windows 11, 10, 8, and 7 computers. This network scanner software offers access to various network resources, including HTTPS, HTTP, FTP, and shared folders. It presents various types of information about local network. Advanced IP Scanner can detect and analyze all devices connected to your wireless or wired local network. Scan your WiFi network and within just a few seconds you'll be given a list of all the IPs and their device information. Advanced IP Scanner is a fast, robust and easy-to-use multithreaded IP scanner for Windows. With Advanced IP Scanner, you can do this easier than ever before, simply download and install this completely free to use program and start using it right away. If you have a lot of different devices connected to your network, you'd probably like to be able to view and manage those connections. " Free, fast and easy-to-use IP scanner." Angry IP Scanner (or simply ipscan) is an open-source and cross-platform network scanner designed to be fast and simple to use. If screwing into a stud, you’ll likely only need a 3-inch screw ($8 for one lb. The example linked-to above can support up to 4 pictures.The 9 Best Cordless Drills of 2023, According To Testing How to Hang a Heavy Mirror on Plaster How much weight can a picture hanging system hold?īecause a pictures weight is distributed along the entire rail, it can can hold up to 300 pounds, making it the ideal solution for how to hang things on plaster walls. It also gives a unique, museum-like look to any room of your house, whether it's for hanging art in your living room, or smaller pictures in your office space. Since the hanging wires may be clicked onto or slid into the rail wherever you like, you always have flexibility when it comes to hanging and rehanging wall decorations. This system works by simply installing a rail along the wall, and pictures then hang from cables attached to the rail, and are fastened with hooks. The ideal solution for hanging pictures on plaster is to use a picture hanging system like the all-in-one click rail cable hanging kit. How to hang on plaster-walls with a picture hanging system Another best practise is to place a piece of masking tape on the area that you will be drilling into. It is highly recommended to drill a hole first, because this will greatly reduce the risk of the plaster cracking. You can use long wooden plaster screw to hang a picture in a wall stud. Once you've located a stud, you can simply measure 16 inches (the standard spacing of studs) on either side to locate the other studs. Stud finders work by detecting the metal nails that are in the wall studs. To locate a wall stud, you'll need to use a magnetic stud finder. That being said, the wall stud may not be in the ideal location to hang your picture stylistically. Therefore, it's the strongest part of the wall and the ideal place to hang pictures from. As mentioned earlier, the wall stud is where the wooden lath attaches to the wooden frame behind the plaster. Generally speaking, it's best to hang heavy pictures on a wall stud. How to hang heavy things on plaster walls using a wall stud One of plaster wall's downsides, however, is that it's more brittle than drywall and it can break a lot easier. Lastly, plaster wall is more contour friendly and allows home builders to create curves around the ceiling and the edge of the wall. Secondly, plaster wall is thicker than drywall which provides a much needed level of sound-proofing. Drywall on the other hand, is flat and smooth and doesn't have a whole lot of character. First of all, it often has a rugged and uneven surface which provides a stylish, old-home look. However, plaster-wall is making a comeback in some circles. This was mainly due to the fact that they are easier to install and less brittle. Modern homes eventually switched to using drywall panels instead. In a nutshell, a plaster wall is made up of lath attached to wall studs and covered in plaster. In order create a wall with a nice finish, several layers of plaster are coated on top. Nails are used to hold the wooden lath and studs together. Supporting this lath, is a wooden frame called a wall stud. Layered strips of wood, called lath, were placed on top of each other in order to create a thick and sturdy wall. Up until the 1940's, the interior wall of choice, was plaster wall. And while a magnetic wallet sleeve is nice, we can do even better. The MagSafe Leather Wallet attachment highlighted the fact that there are plenty of folks out there that just aren't interested in stuffing multiple things into their pockets every time they go out. While the cases don't work like the MagSafe cases do, I like that you get Pipetto's entire magnetic mounting solution in one shot rather than having to buy additional accessories (or wait for them to be manufactured in the first place). I especially like that the buttons are anodized metal rather than the cheap plastic nubs you get on most cases. What's neat is that, while most magnetic cases interfere with charging, Pipetto has engineered a solution to maintain Qi charging compatibility. Their slim, form-fitting leather cases come with a special metal plate in the case that interacts with the bundled magnetic mount. Pipetto added magnets to their leather cases before Apple decided magnets were cool. Magnetic Leather iPhone Case BUY FROM PIPETTO In the meantime, you've still got great leather options. Usually Apple has a leather case available right away, in fact there was a peek-a-boo folio-style case seen during the keynote, but it hasn't materialized yet. 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No, this isn't a case inspired by Bradley Cooper's character in a movie about mind-altering pharmaceuticals. There are plenty of traditional cases out there for your iPhone 12 Pro. If you don't care about magnets and clear cases aren't your thing, don't worry. Doing so will get you 15% off your next Nimble purchase. I especially like that in every package there's an e-waste recycling bag so that you can properly dispose of your old case (or earbuds or batteries). Nimble has done edge-test drops of up to 6-feet, so you can feel confident that your iPhone 12 Pro is protected from drops. It also has a permanent antimicrobial treatment so that your iPhone stays germ-free. The plastic is treated so that it resist scratches and yellowing, making sure it looks just as clear in a year as it does when you pop it out of the (plastic free) packaging. Nimble cases are made from post-consumer compact discs (which are mostly made out of polycarbonate). If you're looking for a clear case made from a truly unique material, then you'll want to check out these crystal-clear cases from Nimble. Whether you're shopping for yourself or looking for that ideal gift, kate spade's collections have got you covered.Nimble Disc Case for iPhone 12 Pro BUY FROM VERIZON WIRELESS Our products are designed to bring a touch of elegance and whimsy to your daily life. The iPhone 12 is the first major redesign since 2017’s iPhone X, affording case makers an opportunity to come up with all-new designs and to refine models we’ve had good experiences with in. From stylish tech accessories to charming women's handbags, wallets, and more, you'll find the perfect items to complement your unique style. Explore our related collections for even more women's accessories and gifts. With kate spade, your tech is not just a necessity it's a fashion statement!īut that's not all - kate spade has your complete lifestyle covered. 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The Horizon® name and symbols are registered marks of Horizon Blue Cross Blue Shield of New Jersey. The Blue Cross® and Blue Shield® names and symbols are registered marks of the Blue Cross Blue Shield Association. Both are independent licensees of the Blue Cross Blue Shield Association. Communications are issued by Horizon Blue Cross Blue Shield of New Jersey in its capacity as administrator of programs and provider relations for all its companies. Medicare Supplement plans are provided by Horizon Insurance Company. Products are provided by Horizon NJ Health. Enrollment in Horizon NJ TotalCare (HMO D-SNP) depends on contract renewal. Horizon NJ Health has a Medicare contract and a contract with the State of New Jersey Medicaid Program to offer Horizon NJ TotalCare (HMO D-SNP) an HMO Medicare Advantage Dual Eligible Special Needs plan. ¹ Claim based on NAIC Market Share Report, published 2023. The Braven Health name and symbols are service marks of Braven Health. I was so impressed with how helpful your customer service representatives. The Horizon® name and symbols are registered marks and OMNIA is a service mark of Horizon Blue Cross Blue Shield of New Jersey. Please use the chart below to contact the right team to get your answers. Horizon BCBS of NJ members are eligible to receive a high-quality, top. Enrollment in HIC Medicare products depends on contract renewal. Your Guide to Getting Care Your Health in Focus Who to Contact When You Have a Question Horizon Blue Cross Blue Shield of New Jersey wants you to have the information you need, when you need it. Horizon Insurance Company ("HIC") has a Medicare contract to offer Part D Medicare plans, including group Part D Prescription Drug Plans. Eligibility Information & Enrollment Instructions |
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